KMID : 1151920210030040137
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Chronobiology in Medicine 2021 Volume.3 No. 4 p.137 ~ p.141
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Rest-Activity Pattern and Circadian Phase Alterations Across the Alzheimer¡¯s Disease Clinical Spectrum
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Roh Hyun-Woong
Son Sang-Joon
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Abstract
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Actigraphy-derived locomotor activity recordings are novel and critical tools for evaluating rest-activity pattern and circadian phase in humans. We conducted a narrative review assessing rest-activity pattern and circadian phase alterations within various stages of Alzheimer¡¯s disease, in consideration of the reciprocal associations between neurodegeneration and circadian rhythm disruption in patients with Alzheimer¡¯s disease. The goal of this review was to characterize possible associations between circadian rhythm disruption and neurodegeneration in Alzheimer¡¯s disease. To the best of our knowledge, only two studies have assessed rest-activity pattern and circadian phase alterations in the preclinical Alzheimer¡¯s disease stage and the results of the studies were inconsistent. Several studies have evaluated rest-activity pattern and circadian phase alterations in patients with Alzheimer¡¯s dementia. The most replicated findings were delayed phase and increased activity fragmentation, represented as increased intra-daily variability. Unfortunately, many studies performed in dementia patients have not examined neuroimaging biomarkers or structured neuropsychological tests, thus limiting the specification of dementia clinical diagnoses. Future studies should consider a more comprehensive evaluation of various clinical and biomarker characteristics in patients with dementia or Alzheimer¡¯s disease.
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KEYWORD
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Actigraphy, Alzheimer¡¯s disease, Circadian phase, Rest-activity pattern
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